VITT risk falls – but doesn’t disappear – after a second dose of AZ, so you may want to factor that into your decision. Provincial governments stopped offering AZ, a viral-vector vaccine, as a first dose because of the risk of VITT. The advice doesn’t mean people can’t still choose AstraZeneca if they want, or if they are allergic to the mRNA vaccines. The guidance is based on growing evidence that a second dose of an mRNA vaccine produces a stronger immune response, and because of the risk of a rare but sometimes fatal blood-clotting disorder called vaccine-induced thrombotic thrombocytopenia, or VITT, associated with getting AstraZeneca. On June 17, the National Advisory Committee on Immunization said it is now recommending people who got the Oxford-AstraZeneca vaccine first should get Pfizer-BioNTech or Moderna for their second shot. Blair Gable/Reuters What if I took the Oxford-AstraZeneca vaccine first? What should I do for my second dose? Prime Minister Justin Trudeau is inoculated with AstraZeneca's vaccine at an Ottawa pharmacy on April 23. “They are based on the same technology they have very, very similar spike segments they trigger the body to do the exact same thing,” said Zain Chagla, an infectious-disease physician at McMaster University.
The Pfizer and Moderna shots have performed almost identically in clinical trials and real-world studies.
Both use messenger RNA technology to trick immune cells into displaying a piece of the coronavirus’s telltale spike protein, spurring the immune system to make antibodies against SARS-CoV-2, the virus that causes COVID-19. But from a scientific perspective, experts agree it shouldn’t be a problem to mix-and-match COVID-19 vaccines that use the same platform, as the Pfizer and Moderna shots do. Getting the second COVID-19 vaccine shot If I received a first shot of the Pfizer-BioNTech product, can I switch to Moderna for my second? Or vice versa?įrom a logistical perspective, that depends on availability and policy in your home province.
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Log In Create Free AccountĪm I eligible for a first or second dose? Check provincial rules here.
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